| Identification | Back Directory | [Name]
DFMO | [CAS]
70052-12-9 | [Synonyms]
DFMO
RFI 71782
Ccris 3295
EFLORNITINE
Brn 2250529
DL-EFLORNITHINE
H-DL-(F2ME)ORN-OH
DIFLUOROMETHYLORNITHINE
α-Difluoromethylornitine
DFMO hydrochloride hydrate
DIFLUOROMETHYLORNITHINE(RG)
DL-(α-difluoromethyl)Orn-OH
2-(difluoromethyl)-ornithin
Eflornithine base （racemic)
alpha-difluromethylornithine
α-Difluoromethyl-DL-ornithine
H-ALPHA-DIFLUORO-ME-DL-ORN-OH
alpha-difluoromethylornithine
Ornithine, 2-(difluoromethyl)-
ALPHA-DIFLUORO-ME-DL-ORNITHINE
DL-ALPHA-DIFLUOROMETHYLORNITHINE
H-DL-(ALPHA-DIFLUOROMETHYL)ORN-OH
ALPHA-DIFLUOROMETHYL-DL-ORNITHINE
DL-2-(DIFLUORO-METHYL)-ORNITHINE HCL
α-Difluoromethyl-DL-ornithine≥ 98% (NMR)
2-(Difluoromethyl)-2,5-diaminovaleric acid
DL-α-Difluoromethylornithine hydrochloride
DL-2-(Difluoromethyl)-ornithinehydrochloride
96020-91-6 (Mono-hydrochloride, monohydrate)
DL-α-Difluoromethylornithine hydrochloride hydrate
DL-α-Difluoromethylornithine hydrate hydrochloride
DL-ALPHA-DIFLUOROMETHYLORNITHINE HYDROCHLORIDE HYDRATE
alpha,delta-Diamino-alpha-(difluoromethyl)valeric acid
2-(Difluoromethyl)ornithine hydrate hydrochloride, DFMO hydrate hydrochloride
DL-α-Difluoromethylornithine hydrochloride hydrate,2-(Difluoromethyl)ornithine hydrochloride hydrate, DFMO hydrochloride hydrate, Eflornithine hydrochloride hydrate | [Molecular Formula]
C6H12F2N2O2 | [MDL Number]
MFCD00221766 | [MOL File]
70052-12-9.mol | [Molecular Weight]
182.17 |
| Chemical Properties | Back Directory | [Melting point ]
138 °C | [Boiling point ]
347.0±42.0 °C(Predicted) | [density ]
1.1800 (estimate) | [storage temp. ]
Store at 0°C | [solubility ]
H2O: >10 mg/mL, soluble
| [form ]
solid
| [pka]
1.22±0.44(Predicted) | [color ]
white
|
| Hazard Information | Back Directory | [Chemical Properties]
Off-white powder | [Uses]
DL-α-Difluoromethylornithine hydrochloride hydrate has been used to reduce the effects of arginine on cell proliferation. It has also been used to investigate the effect of bisphenol A (BPA) on the migration of an established ovine trophectoderm (oTr1) cell line. | [Definition]
ChEBI: Eflornithine is a fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2. It has a role as a trypanocidal drug. It is a fluoroamino acid and an alpha-amino acid. It is functionally related to an ornithine. | [General Description]
Difluoromethylornithine is a?fluorinated ornithine analog, which acts as a rate-limiting enzyme of polyamine biosynthesis. It is used to treat female facial hirsutism and human African trypanosomiasis. Difluoromethylornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer. It exhibits cytostatic?effects on mammalian cells and tissues. | [Biological Activity]
Inhibitor of ornithine decarboxylase that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity. | [Biochem/physiol Actions]
Difluoromethylornithine (Eflornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. |
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