| Identification | Back Directory | [Name]
QUAZINONE | [CAS]
70018-51-8 | [Synonyms]
Posicor
Quazinona
QUAZINONE
R 13-6438
RO 13-6438
Quazinonum
Unii-D1Q7F6C2fp
Quazinonum [latin]
Quazinona [spanish]
Quazinone (Ro 13-6438)
Ro 13-6438 (Quazinone)
(3R)-6-Chloro-1,5-dihydro-3-methylimidazo[2,1-b]quinazolin-2(3H)-one
Imidazo(2,1-B)quinazolin-2(3H)-one, 6-chloro-1,5-dihydro-3-methyl-, (R)-
IMidazo[2,1-b]quinazolin-2(3H)-one, 6-chloro-1,5-dihydro-3-Methyl-, (3R)- | [Molecular Formula]
C11H10ClN3O | [MDL Number]
MFCD00211176 | [MOL File]
70018-51-8.mol | [Molecular Weight]
235.67 |
| Chemical Properties | Back Directory | [storage temp. ]
RT | [solubility ]
ethanol: soluble1mg/mL | [form ]
White to off-white solid. | [color ]
white | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months |
| Hazard Information | Back Directory | [Description]
Ro 13-6438 (70018-51-8) is a selective inhibitor of phosphodiesterase III (PDE III, IC50 = 0.6 μM). | [Uses]
Cardiotonic. | [Uses]
Quazinone (Ro 13-6438) is a phosphodiesterase inhibitor and novel cardiotonic agent with vasodilating properties. | [References]
1) Eigenmann et al. (1984) Cardiovascular profile of Ro 13-6438, a novel positive inotropic agent with vasodilating properties; J. Cardiovasc. Pharmacol., 6 511
2) Holck et al. (1984) Studies on the mechanism of positive inotropic activity of Ro 13-6438, a structurally novel cardiotonic agent with vasodilating properties; J. Cardiovasc. Pharmacol. 6 520 |
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