| Identification | Back Directory | [Name]
ATRACTYLINE(DISCONTINUED)(SH) | [CAS]
6989-21-5 | [Synonyms]
Atractyline
ATRACTYLINE(DISCONTINUED)(SH)
(4aS)-4,4aα,5,6,7,8,8a,9-Octahydro-3,8aβ-dimethyl-5-methylenenaphtho[2,3-b]furan
(4aS,8aR)-3,8a-diMethyl-5-Methylene-4,4a,5,6,7,8,8a,9-octahydronaphtho[2,3-b]furan
(4aS,8aR)-4,4a,5,6,7,8,8a,9-Octahydro-3,8a-dimethyl-5-methylene-naphtho[2,3-b]furan
Naphtho[2,3-b]furan, 4,4a,5,6,7,8,8a,9-octahydro-3,8a-diMethyl-5-Methylene-, (4aS,8aR)- | [Molecular Formula]
C15H20O | [MDL Number]
MFCD00210477 | [MOL File]
6989-21-5.mol | [Molecular Weight]
216.32 |
| Chemical Properties | Back Directory | [Melting point ]
61-63℃ | [Boiling point ]
287.1±19.0℃ (760 Torr) | [density ]
1.02±0.1 g/cm3 (20 ºC 760 Torr) | [Fp ]
121.7±8.3℃ | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Soild | [color ]
Faint red to very dark red | [LogP]
5.570 |
| Hazard Information | Back Directory | [Uses]
Atractylone (Atractylon) is a sesquiterpenoid extracted from Atractylodis Rhizoma. Atractylone (Atractylon) alleviates influenza A virus (IAV)-induced lung injury via regulating the TLR7 signaling pathway, and acts as a promising agent for IAV treatment. Atractylone (Atractylon) inhibits the degranulation of mast cell and exhibits potential for the treatment of mast cell-mediated allergic reactions[1][2]. | [Definition]
ChEBI: Atractylone is a sesquiterpenoid. | [Biological Activity]
Atractylon is a main active component of Atractylodis Rhizoma th at exhibits antibacterialantiviralanti-inflammatoryanti-allergicanticancergastroprotective and neuroprotective activities. Atractylon inhibits proliferationinduces apoptosis and blocks invasion in varies hepatic cancer cell lines. It inhibits the expression of Bcl-2 and promotes the expression of Bax. | [target]
IL Receptor | VEGFR | Histamine Receptor | [References]
[1] Cheng Y, et al. Antiviral activities of atractylon from Atractylodis Rhizoma. Mol Med Rep. 2016 Oct;14(4):3704-10. DOI:10.3892/mmr.2016.5713
[2] Han NR, et al. Inhibitory effects of atractylone on mast cell-mediated allergic reactions. Chem Biol Interact. 2016 Oct 25;258:59-68. DOI:10.1016/j.cbi.2016.08.015 |
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