| Identification | Back Directory | [Name]
Xanthohumol I | [CAS]
688360-06-7 | [Synonyms]
Xanthohumol I
2-Propen-1-one, 1-[2,3-dihydro-4-hydroxy-2-(1-hydroxy-1-methylethyl)-6-methoxy-7-benzofuranyl]-3-(4-hydroxyphenyl)-, (2E)- | [Molecular Formula]
C21H22O6 | [MOL File]
688360-06-7.mol | [Molecular Weight]
370.4 |
| Hazard Information | Back Directory | [Uses]
Xanthohumol I, a chalkone, is a derivative of Xanthohumol (HY-N1067). Xanthohumol is a Cholinesterase (ChE) inhibitor, which inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) wih IC50s of 71.34 μM and 32.67 μM, respectively. The hydroxy compound of Xanthohumol (3-hydroxy-xanthohumol), also shoes inhibitory effect on AChE and BChE with IC50s of 51.25 μM and 63.07 μM[1]. | [IC 50]
AChE; BChE | [References]
[1] Orhan IE, et al. Molecular modeling and in vitro approaches towards cholinesterase inhibitory effect of some natural xanthohumol, naringenin, and acyl phloroglucinol derivatives. Phytomedicine. 2018 Mar 15;42:25-33. DOI:10.1016/j.phymed.2018.03.009 |
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