| Identification | Back Directory | [Name]
L-Serine, L-phenylalanyl-L-leucyl-L-prolylglycyl-L-glutaminyl-L-phenylalanyl-L-alanyl-L-phenylalanyl- | [CAS]
686324-96-9 | [Synonyms]
L-Serine, L-phenylalanyl-L-leucyl-L-prolylglycyl-L-glutaminyl-L-phenylalanyl-L-alanyl-L-phenylalanyl- | [Molecular Formula]
C51H68N10O12 | [MOL File]
686324-96-9.mol | [Molecular Weight]
1013.15 |
| Chemical Properties | Back Directory | [Boiling point ]
1456.3±65.0 °C(Predicted) | [density ]
1.297±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [pka]
3.01±0.10(Predicted) | [Water Solubility ]
Soluble to 1 mg/ml in water |
| Hazard Information | Back Directory | [Description]
Chemokine-like receptor 1 (CMKLR1) agonist (EC50 = 42 nM). Corresponds to C-terminal of full length mouse Chemerin, amino acids 148 - 156. | [Uses]
Chemerin-9, mouse (Chemerin148-156, mouse) is a C-terminal nonapeptide of chemerin. Chemerin-9, mouse is a ligand for ChemR23 (EC50 = 42 nM). Chemerin-9, mouse reduces basal lipolysis in primary mouse white adipocytes(IC50 = 3.3 nM). Chemerin-9, mouse enhances memory and relieves Aβ1-42-induced memory impairment in AD mice. Chemerin-9, mouse also inhibits atherogenesis[1][2][3]. | [storage]
Store at -20°C | [References]
[1] Shimamura K, et al. Identification of a stable chemerin analog with potent activity toward ChemR23. Peptides. 2009 Aug;30(8):1529-38. DOI:10.1016/j.peptides.2009.05.030
[2] Sato K, et al. Chemerin-9, a potent agonist of chemerin receptor (ChemR23), prevents atherogenesis. Clin Sci (Lond). 2019 Aug 20;133(16):1779-1796. DOI:10.1042/CS20190336
[3] Lei Z, et al. Chemerin-9 Peptide Enhances Memory and Ameliorates Aβ1-42-Induced Object Memory Impairment in Mice. Biol Pharm Bull. 2020 Feb 1;43(2):272-283. DOI:10.1248/bpb.b19-00510 |
|
| Company Name: |
R&D Systems, Inc
|
| Tel: |
18003437475 18003437475 |
| Website: |
www.rndsystems.com |
|