| Identification | Back Directory | [Name]
N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea | [CAS]
685506-42-7 | [Synonyms]
GSK 264220A
1-(2-methyl-5-piperidin-1-ylsulfonylfuran-3-yl)-3-phenylurea
N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea | [Molecular Formula]
C17H21N3O4S | [MDL Number]
MFCD02679009 | [MOL File]
685506-42-7.mol | [Molecular Weight]
363.43 |
| Chemical Properties | Back Directory | [density ]
1.375±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
Soluble to 100 mM in DMSO and to 10 mM in ethanol | [form ]
Powder | [pka]
13.63±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
GSK 264220A is an endothelial lipase and lipoprotein lipase inhibitor, expected to be useful for the treatment of cardiovascular disease. | [Biological Activity]
GSK264220A is a potentactive site-targetingcovalent inhibitor against endothelial lipase (EL or LIPG; IC50 = 130 nM) and lipoprotein lipase (LPL or LIPD; IC50 = 100 nM). GSK264220A reduces NeuT expression - or CoCl2 treatment-induced intracellular triacylglycerol & lipid droplets (TAG & LD) increase in MCF-7 (16 & 32 nM) and suppresses LPL-depenent melanoma survival (by ~50% at 18.75 μM; WM852WM1361). When applied in mice in vivo (30 mg/kg ip.)GSK264220A21 enhances lipid nanoparticles-mediated siRNAs delivery & gene-silencing efficacy. | [storage]
Store at +4°C |
|
| Company Name: |
R&D Systems, Inc
|
| Tel: |
18003437475 18003437475 |
| Website: |
www.rndsystems.com |
| Company Name: |
Merck KGaA
|
| Tel: |
(+86) 21 2033 8288 |
| Website: |
http://www.sigmaaldrich.cn |
|