| Identification | Back Directory | [Name]
3-CYANOMETHYLBENZOIC ACID METHYL ESTER | [CAS]
68432-92-8 | [Synonyms]
Methyl m-(cyanomethyl)benzoate
METHYL 3-(CYANOMETHYL) BENZOATE
3-CYANOMETHYLBENZOIC ACID METHYL ESTER
Benzoicacid, 3-(cyanomethyl)-, methyl ester
high quality 3-CYANOMETHYLBENZOIC ACID METHYL ESTER | [Molecular Formula]
C10H9NO2 | [MDL Number]
MFCD07783720 | [MOL File]
68432-92-8.mol | [Molecular Weight]
175.18 |
| Hazard Information | Back Directory | [Uses]
Methyl 3-(cyanomethyl)benzoate is used as an intermediate in organic synthesis for the preparation of other compounds such as 3-(cyanomethyl)benzoic acid. | [Synthesis]
Methyl 3-(cyanomethyl)benzoate is synthesised using Methyl 3-(bromomethyl)benzoate as raw material by chemical reaction. The specific synthesis steps are as follows:
(i) To a solution of methyl 3-bromobenzoate (10.0 g, 44 mmol) in acetonitrile (100 mL) were added potassium cyanide (5.7 g, 87 mmol) and 18-crown-6 (1.0 g), and the mixture was stirred at room temperature for 3 days. The reaction mixture was filtered, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane=5/95-->30/70), and the fraction containing the object product was concentrated under reduced pressure to give the title compound (7.0 g, 91percent) as a colorless oil. 1H-NMR (DMSO-d6, 300 MHz) δ 3.88 (3H, s), 4.17 (2H, s), 7.57 (1H, t, J = 7.6 Hz), 7.61 - 7.69 (1H, m), 7.88 - 7.95 (1H, m), 7.97 (1H, br s).
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