| Identification | Back Directory | [Name]
Sorbinil | [CAS]
68367-52-2 | [Synonyms]
CP-45634
(S)-(+)-Sorbinil
Sorbinil >=98% (HPLC)
(+)-(4S)-6-Fluorospiro[chroman-4,4′-imidazolidine]-2′,5′-dione
(4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione
(4S)-6-Fluorospiro[2H-1-benzopyran-4(3H),4'-imidazolidine]-2',5'-dione
(S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione
(4S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione
(4S)-6'-Fluoro-2',3'-dihydrospiro[imidazolidine-4,4'-[4H][1]benzopyran]-2,5-dione
Spiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione, 6-fluoro-2,3-dihydro-, (4S)- | [Molecular Formula]
C11H9FN2O3 | [MDL Number]
MFCD00867380 | [MOL File]
68367-52-2.mol | [Molecular Weight]
236.2 |
| Chemical Properties | Back Directory | [Melting point ]
241-243° | [alpha ]
D25 +54.0° (c = 1 in methanol) | [density ]
1.52 | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥20mg/mL | [form ]
powder | [pka]
8.91±0.20(Predicted) | [color ]
white to off-white | [optical activity]
[α]/D +50 to +60°, c = 1 in methanol |
| Hazard Information | Back Directory | [Uses]
Enzyme inhibitor (aldose reductase). | [Definition]
ChEBI: An azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring. | [Biochem/physiol Actions]
Sorbinil decreases the level of sorbitol in red blood cells and increases the velocity of nerve conduction. It maintains the myo-inositol content in the nerve and prevents the reduction of sodium-potassium ATPase activity. This action is beneficial in providing symptomatic relief in patients with diabetic neuropathy. | [in vivo]
Sorbinil (10 mg/kg; ip; single dose ) attenuates LPS-induced uveitis in mice eyes[2].
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