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ChemicalBook--->CAS DataBase List--->680571-51-1

680571-51-1

680571-51-1 Structure

680571-51-1 Structure
IdentificationBack Directory
[Name]

KIGAMICIN C
[CAS]

680571-51-1
[Synonyms]

KIGAMICIN C
Oxazolo[3,2-b]xantheno[4',3',2':4,5][1,3]benzodioxino[7,6-g]isoquinoline-16,19-dione, 3-[[(2S,5S,6R)-5-[(2,6-dideoxy-3-O-methyl-β-D-arabino-hexopyranosyl)oxy]tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-1,2,3,4,8a,9,11,11a,13,14-decahydro-1,4,17,18-tetrahydroxy-11a-methyl-, (1S,3R,4S,8aR,11aR)-
[Molecular Formula]

C41H47NO16
[MDL Number]

MFCD09954098
[MOL File]

680571-51-1.mol
[Molecular Weight]

809.81
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
[form ]

Yellow powder.
Hazard InformationBack Directory
[Uses]

Kigamicin C is a novel antibiotic antiproliferative with novel action.
[Uses]

Kigamicin C was discovered by an anti-austerity strategy, targeting cancer cells' tolerance to starvation. It selectively kills PANC-1 cells (a pancreatic cell line) at concentrations 100 times lower under nutrient starved conditions than in normal conditions. The mechanism of action is proposed to be via blockade of aPKB/Akt activation, caused by the withdrawal of nutrients. It is active in vivo against a human pancreatic cancer xenograft model. Kigamicin C also inhibits the growth of Gram positive bacteria including MRSA, but is not active against Gram negative bacteria.
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