| Identification | Back Directory | [Name]
2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid | [CAS]
68003-38-3 | [Synonyms]
Einecs 268-121-3
SLC25A1 inhibitor CTPI-2
2-(4'-Chloro-3'-nitrobenzenesulfonamido)benzoic acid
2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid
Benzoic acid, 2-(((4-chloro-3-nitrophenyl)sulfonyl)amino)-
2-(4-Chloro-3-nitrophenylsulfonylamino)benzenecarboxylic acid | [EINECS(EC#)]
268-121-3 | [Molecular Formula]
C13H9ClN2O6S | [MDL Number]
MFCD00129907 | [MOL File]
68003-38-3.mol | [Molecular Weight]
356.74 |
| Hazard Information | Back Directory | [Biological Activity]
CTPI-2 is a selective mitochondrial citrate transporter (SLC25A1) inhibitor th at displays H1299 anti-proliferation activity in a SLC25A1-dependent manner (IC50 <10 μM). When compared with CTPI-1CTPI-2 exhibits 20-fold higher target affinity (hSLC25A1 KD = 3.5 μM vs. 63.6 μMrespectively) and is ~1000-fold more potent against H1299 sphere-forming capacity. CTPI-2 inhibits mitochondrial respiration and formation of patient NSCLC tumors-derived CSCs spheres in cultures (10-50 μM)as well as suppresses the growth of patent-derived NSCLC exnografts in mice in vivo (28 mg/kg q.o.d. i.p.). |
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