| Identification | Back Directory | [Name]
KYL | [CAS]
676657-00-4 | [Synonyms]
KYL
KYL peptide
L-Leucine, L-lysyl-L-tyrosyl-L-leucyl-L-prolyl-L-tyrosyl-L-tryptophyl-L-prolyl-L-valyl-L-leucyl-L-seryl-L-seryl- | [Molecular Formula]
C74H108N14O17 | [MDL Number]
MFCD30182273 | [MOL File]
676657-00-4.mol | [Molecular Weight]
1465.73 |
| Chemical Properties | Back Directory | [Boiling point ]
1728.5±65.0 °C(Predicted) | [density ]
1.290±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
3.29±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble to 2 mg/ml in water | [Sequence]
H-Lys-Tyr-Leu-Pro-Tyr-Trp-Pro-Val-Leu-Ser-Ser-Leu-OH |
| Hazard Information | Back Directory | [Uses]
KYL peptide, an antagonistic peptide, selectively targets EphA4 receptor (IC50:4.22 μM, Kd:1.3 μM). KYL peptide binds to the ligand-binding domain of EphA4, effectively alleviates Aβ-induced synaptic dysfunction and synaptic plasticity defects in AD mice. KYL peptide can promote nerve regeneration after injury and modulating immune responses[1][2][3]. | [Biological Activity]
KYL is a potent and selective EphA4 receptor tyrosine kinase antagonist th at inhibits EphA4-EphrinA5 interactions. KYL binds to the ephrin-binding domain of EphA4. | [IC 50]
EphA4: 4.22 μM μM (IC50); EphA4: 1.30 μM (Ki) | [storage]
Store at -20°C | [References]
[1] Wu B, et.al. HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery. Chem Biol. 2013 Jan 24;20(1):19-33. DOI:10.1016/j.chembiol.2012.10.015
[2] Lamberto I, et, al. Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem J. 2012 Jul 1;445(1):47-56. DOI:10.1042/BJ20120408
[3] Fu AKY, et, al. Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9959-64. DOI:10.1073/pnas.1405803111 |
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