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ChemicalBook--->CAS DataBase List--->675126-08-6

675126-08-6

675126-08-6 Structure

675126-08-6 Structure
IdentificationBack Directory
[Name]

(1R,4S)-N-Desmethyl Sertraline Hydrochloride
[CAS]

675126-08-6
[Synonyms]

CS-2586
DSP-225289
Dastroline
Dasotraline HCl
Dastroline HCl salt
SEP-225289 hydrochloride
Sertraline Impurity 4 HCl
SEP-225289;DSP-225289;DASTROLINE
(1R,4S)-N-Desmethyl sertraline HCl
(1R,4S)-N-Desmethyl Sertraline Hydrochloride
(1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine Hydrochlorid
(1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine Hydrochloride
(1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride
[Molecular Formula]

C16H15Cl2N.ClH
[MOL File]

675126-08-6.mol
[Molecular Weight]

328.668
Chemical PropertiesBack Directory
[Melting point ]

270-272°C (dec.)
[storage temp. ]

Hygroscopic, -20°C Freezer, Under Inert Atmosphere
[solubility ]

Methanol (Slightly)
[form ]

Solid
[color ]

White
Hazard InformationBack Directory
[Chemical Properties]

White Solid
[Uses]

(1R,4S)-N-Desmethyl Sertraline Hydrochloride is a metabolite of Sertraline, Used for treatment of CNS disorders.
[Uses]

A metabolite of Sertraline. Used for treatment of CNS disorders.
[in vivo]

Acute administration of dasotraline dose-dependently decreases the spontaneous firing rate of LC NE, VTA DA and DR 5-HT neurons through the activation of α2, D2 and 5-HT1A autoreceptors, respectively. Dasotraline predominantly inhibits the firing rate of LC NE neurons while producing only a partial decrease in VTA DA and DR 5-HT neuronal discharge. SEP-225289 is equipotent at inhibiting 5-HT and NE transporters since it prolongs to the same extent the time required for a 50% recovery of the firing activity of dorsal hippocampus CA3 pyramidal neurons from the inhibition induced by microiontophoretic application of 5-HT and NE[1]. Average dopamine and serotonin transporter occupancies increase with increasing doses of SEP-225289. Mean dopamine and serotonin transporter occupancies are 33%±11% and 2%±13%, respectively, for 8 mg; 44%±4% and 9%±10%, respectively, for 12 mg; and 49%±7% and 14%±15%, respectively, for 16 mg[2].

[storage]

Store at -20°C
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