| Identification | Back Directory | [Name]
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE | [CAS]
67469-81-2 | [Synonyms]
CS-1078
GBR 12935 HCl
GBR-12935 2HCL
GBR 12935 (hydrochloride)
GBR 12935 DIHYDROCHLORIDE
GBR-2935(dihydrochloride)
GBR 12935 dihydrochloride, >=98%
1-(2-(BENZHYDRYLOXY)ETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE.2HCL
1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
Piperazine,1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-, hydrochloride (1:2) | [Molecular Formula]
C28H36Cl2N2O | [MDL Number]
MFCD00083175 | [MOL File]
67469-81-2.mol | [Molecular Weight]
487.5 |
| Chemical Properties | Back Directory | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
H2O: 20 mg/mL with warming | [form ]
powder | [color ]
white | [Water Solubility ]
H2O: 20mg/mL (with warming) |
| Hazard Information | Back Directory | [Uses]
A very potent and selective inhibitor of dopamine uptake | [Definition]
ChEBI: A hydrochloride salt that is obtained by reaction of 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine with two equivalents of hydrogen chloride. Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal memb
anes). | [Biochem/physiol Actions]
GBR 12935 inhibits the dopamine and norepinephrine transporters with Kis of 21.5 nM and 225 nM, respectively. It does not inhibit the serotonin transporter (Ki = 6.5 mM). GBR 12935 binds to a nondopaminergic piperazine site in blood platelets and brain that has been identified as cytochrome P450. | [in vivo]
GBR 12935 dihydrochloride (1-32 mg/kg; repeat injection; 7 d) elevates locomotion activity to a greater extent in C57BL/6J mice than DBA/2J mice, and (10 mg/kg; injection; 7 d) results few mice sensitized to cocaine-induced stereotypy with repeated injections[3].
| Animal Model: | Adult male DBA/2J and C57BL/6J mice (22-30 g)[3] | | Dosage: | 1.0, 3.2, 10, 32 mg/kg | | Administration: | Repeat injection; for 7 days | | Result: | Elevated locomotion activity to a greater extent in C57BL/6J mice than DBA/2J mice.
No stereotypy was induced by an eighth day challenge of 10 mg/kg GBR 12935 dihydrochloride in mice pretreated with seven dally injections of either 32 mg/kg cocaine or saline. |
| [storage]
Store at -20°C |
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