| Identification | Back Directory | [Name]
moronic acid | [CAS]
6713-27-5 | [Synonyms]
moronicaci
moronic acid
3-Oxooleana-18-ene-28-oic acid
Olean-18-en-28-oic acid,3-oxo-
3-Oxo-5α-olean-18-en-28-oic acid | [Molecular Formula]
C30H46O3 | [MDL Number]
MFCD11113464 | [MOL File]
6713-27-5.mol | [Molecular Weight]
454.68 |
| Chemical Properties | Back Directory | [Melting point ]
212 °C(dec.) | [Boiling point ]
550.0±50.0 °C(Predicted) | [density ]
1.09±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.59±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Moronic Acid and its derivatives can have antidiabetic activity by inhibiting PTP-1B. Moronic Acid is also shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization in rat models. | [Definition]
ChEBI: A pentacyclic triterpenoid that is olean-18-ene substituted at position 3 by an oxo group and position 28 by a carboxy group. | [in vivo]
Moronic Acid (5-10 mg/kg, i.g., once daily, 20 days) regulates the ROS - NF - κB - NLRP3 signaling pathway in mice by inhibiting ROS, improving inflammatory bowel disease[2].
Moronic Acid extends the survival time of HSV-1 infected mice and slows the progression of skin lesions[3]. | Animal Model: | Mice induced by DSS[2] | | Dosage: | 5, 10 mg/kg; daily; 20 days | | Administration: | i.g. | | Result: | Inhibited intestinal macrophage M1 polarization, inhibited the expression of inflammatory factors, and reduced ROS-NF-κB-NLRP3 signaling levels. |
| [IC 50]
NLRP3 |
|
| Company Name: |
BioBioPha Co., Ltd.
|
| Tel: |
0871-65217109 13211707573; |
| Website: |
http://www.biobiopha.com |
| Company Name: |
TCI Europe
|
| Tel: |
320-37350700 |
| Website: |
https://www.tcichemicals.com/de/de/index.html |
| Company Name: |
TCI AMERICA
|
| Tel: |
800-4238616 |
| Website: |
https://www.tcichemicals.com/en/us/index.html |
|