| Identification | Back Directory | [Name]
1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethan-1-one | [CAS]
670270-31-2 | [Synonyms]
IU1 47
inhibit,IU1 47,Deubiquitinase,IU-1-47,IU1-47,DUBs,Inhibitor,IU147
1-[1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-piperidinyl)ethanone
Ethanone, 1-[1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-piperidinyl)-
1-(1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethan-1-one | [Molecular Formula]
C19H23ClN2O | [MDL Number]
MFCD03761987 | [MOL File]
670270-31-2.mol | [Molecular Weight]
330.85 |
| Chemical Properties | Back Directory | [Boiling point ]
475.1±45.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 16.67 mg/mL (50.39 mM; Need ultrasonic) | [form ]
A solid | [pka]
7.08±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
IU1-47 is a potent and specific USP14 inhibitor with an IC50 of 0.6 μM. IU1-47 inhibits IsoT/USP5 with an IC50 of 20 μM. IU1-47 induces tau elimination in cultured neurons[1]. | [Biological Activity]
IU1-47 is a potent and selective inhibitor of the deubiquitinating enzyme UPS14. IU1-47 enhances protein degradation including human wild-type and pathological Tau forms in neurons. | [storage]
Store at -20°C | [References]
[1] Boselli M, et al. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J Biol Chem. 2017 Nov 24;292(47):19209-19225. DOI:10.1074/jbc.M117.815126 |
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