| Identification | Back Directory | [Name]
(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME | [CAS]
667463-85-6 | [Synonyms]
CS-1611
BIO-ACETOXIME
GSK-3 INHIBITOR X
GSK3 Inhibitor IX2
6-Bromoindirubin acetoxime
BIO-Acetoxime >=98% (HPLC)
6-Bromoindirubin-3′-acetoxime
BIO-acetoxime(GSK-3 Inhibitor)
BIO-acetoxime GSK3 Inhibitor IX2
BIO-acetoxime (GSK-3 Inhibitor X)
(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME
GSK3 INHIBITOR X6-BROMOINDIRUBIN-3'-ACETOXIME
(2Z,3E)-3-(Acetoxyimino)-6'-bromo-[2,3'-biindolinylidene]-2'-one
(3Z)-3-[(3E)-3-[(Acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-Indol-2-one
2H-Indol-2-one, 3-[(3E)-3-[(acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-, (3Z)- | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C18H12BrN3O3 | [MDL Number]
MFCD09037533 | [MOL File]
667463-85-6.mol | [Molecular Weight]
398.21 |
| Chemical Properties | Back Directory | [density ]
1.69±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
H2O: soluble2mg/mL (clear solution, warmed) | [form ]
powder | [pka]
9.22±0.20(Predicted) | [color ]
, dark red to purple | [Water Solubility ]
H2O: 2mg/mL (clear solution, warmed) |
| Hazard Information | Back Directory | [Uses]
BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. It also induces Wnt signaling and inhibits CD8+ T cell effector differentiation. | [Biological Activity]
Selective GSK-3 α / β inhibitor (IC 50 values are 0.01, 2.4, 4.3 and 63 μ M for GSK-3 α / β , CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation. | [storage]
Store at +4°C |
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