| Identification | Back Directory | [Name]
Benzoic acid, 4-chloro-2-[[2-(1-naphthalenyloxy)acetyl]amino]- | [CAS]
667411-04-3 | [Synonyms]
TRPM4-IN-2
Benzoic acid, 4-chloro-2-[[2-(1-naphthalenyloxy)acetyl]amino]- | [Molecular Formula]
C19H14ClNO4 | [MOL File]
667411-04-3.mol | [Molecular Weight]
355.77 |
| Chemical Properties | Back Directory | [Boiling point ]
631.9±55.0 °C(Predicted) | [density ]
1.425±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
3.00±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer[1][2]. | [IC 50]
TRPM4: 0.16 μM (IC50) | [References]
[1] Borgstr?m A, et al. Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions. J Mol Biol. 2021 Aug 20;433(17):166665. DOI:10.1016/j.jmb.2020.09.024
[2] Stok?osa P, et al. Investigation of Novel Small Molecular TRPM4 Inhibitors in Colorectal Cancer Cells. Cancers (Basel). 2021 Oct 28;13(21):5400. DOI:10.3390/cancers13215400 |
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