| Identification | Back Directory | [Name]
N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide | [CAS]
66644-81-3 | [Synonyms]
LIR166
VERALIPRIDE
Velaripride
N-[(1-Allyl-2-pyrrolidinyl)methyl]-5-sulphamoyl-2-veratramide
N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide
N-[(1-Allylpyrrolidin-2-yl)methyl]-2,3-dimethoxy-5-sulfamoylbenzamide
2,3-diMethoxy-N-{[1-(prop-2-en-1-yl)pyrrolidin-2-yl]Methyl}-5-sulfaMoylbenzaMide
Benzamide, 5-(aminosulfonyl)-2,3-dimethoxy-N-[[1-(2-propen-1-yl)-2-pyrrolidinyl]methyl]- | [EINECS(EC#)]
266-435-5 | [Molecular Formula]
C17H25N3O5S | [MDL Number]
MFCD00867658 | [MOL File]
66644-81-3.mol | [Molecular Weight]
383.46 |
| Chemical Properties | Back Directory | [Melting point ]
128 °C | [density ]
1.230±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
Chloroform (Slightly), DMSO (Slightly) | [form ]
Solid | [pka]
10.02±0.60(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Originator]
Agreal,Delagrange,France,1980 | [Uses]
Labelled Veralipride, a synthetic benzamide derivative with antidopaminergic action, is effective in reducing the frequency and severity of hot flashes associated with menopausal hypoestrogenism, gain
ing interest as a non-hormonal treatment for climacteric flushing. | [Uses]
Veralipride, a synthetic benzamide derivative with antidopaminergic action, is effective in reducing the frequency and severity of hot flashes associated with menopausal hypoestrogenism, gaining interest as a non-hormonal treatment for climacteric flushing. | [Definition]
ChEBI: Veralipride is a sulfonamide. | [Manufacturing Process]
7.8 g (0.03 mol) of 2,3-dimethoxy-5-sulfamoylbenzoic acid, 200 ml of
tetrahydrofuran and 7.3 g (0.045 mol) of carbonyldimidazole are placed in a
500 ml flask fitted with an agitator, a thermometer and a condenser.
The mixture is agitated for 30 minutes at normal temperature, then 6.7 g
(0.948 mol) of 1-allyl-2-aminomethylpyrrolidine is added. The mixture is left
under agitation for 5 hours at 20°C, then the solvent is evaporated under
vacuum and the residue treated with 150 ml of water. The crystals are washed
and dried.
6.9 g of N-(1'-allyl-2'-pyrrolidyl-methyl)-2,3-dimethoxy-5-sulfamoyl-
benzamide is obtained. Yield is 60%; melting point 113°C to 114°C. | [Therapeutic Function]
Menopause treatment |
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