| Identification | Back Directory | [Name]
Butanoic acid, 4-[[5-[(dimethylamino)carbonyl]-2-pyridinyl]dithio]-, 2,5-dioxo-1-pyrrolidinyl ester | [CAS]
663599-05-1 | [Synonyms]
DMAC-SPDB
Butanoic acid, 4-[[5-[(dimethylamino)carbonyl]-2-pyridinyl]dithio]-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C16H19N3O5S2 | [MDL Number]
MFCD20227785 | [MOL File]
663599-05-1.mol | [Molecular Weight]
397.47 |
| Hazard Information | Back Directory | [Uses]
DMAC-SPDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [IC 50]
Disulfide Cleavable Linker; Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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