| Identification | Back Directory | [Name]
DESMETHYL LOPERAMIDE | [CAS]
66164-07-6 | [Synonyms]
dLop
R 20905
DESMETHYL LOPERAMIDE
N-Desmethyl Loperamid
Desmethylloperamide D5
N-Desmethyl Loperamide
Desmethyl loperamide HCl
4-(4-Chlorophenyl)-4-hydroxy-N-methyl-a,a-diphenyl-1-piperidinebutanamide
4-(4-Chlorophenyl)-4-hydroxy-N-Methyl-α,α-diphenyl-1-piperidinebutanaMide
1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N-methyl-α,α-diphenyl- | [Molecular Formula]
C28H31ClN2O2 | [MDL Number]
MFCD08063667 | [MOL File]
66164-07-6.mol | [Molecular Weight]
463.01 |
| Chemical Properties | Back Directory | [Melting point ]
219-221?C | [Boiling point ]
678.3±55.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
DMF: 2 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 1 mg/ml | [form ]
A crystalline solid | [pka]
13.85±0.20(Predicted) |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
A metabolite of Loperamide; a new and improved PET radiotracer for imaging P-gp function | [Uses]
Loperamide is an opiate which potently and selectively activates μ opioid receptors (Ki = 0.16 nM) exclusively in the periphery. N-Desmethyl-loperamide (dLop) is a major metabolite of loperamide. Like loperamide, dLop is a substrate of the ATP-dependent efflux transporter, P-glycoprotein. As a result, both the parent compound and the metabolite display restricted passage through the blood-brain barrier. dLop in biological samples can be analyzed by a variety of methods. | [Definition]
ChEBI: A monocarboxylic acid amide that is the methylamide of 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylbutanoic acid. |
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| Company Name: |
BOC Sciences
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16314854226 |
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www.bocsci.com |
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