| Identification | Back Directory | [Name]
LL-Z-1640-2 | [CAS]
66018-38-0 | [Synonyms]
LL-Z-1640-2
C292, L 783278
(5Z)-7-Oxozeaenol
JNK/p38 inhibitor
(5Z)-7-Oxozeaenol (5Z-7-oxozeaenol)
5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione
(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione | [Molecular Formula]
C19H22O7 | [MDL Number]
MFCD12912700 | [MOL File]
66018-38-0.mol | [Molecular Weight]
362.37 |
| Hazard Information | Back Directory | [Uses]
LL Z1640-2 is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models. | [Biological Activity]
Resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor- β -activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC 50 = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF- κ B (IC 50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF- α -induced apoptosis in vitro . |
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