| Identification | Back Directory | [Name]
ATN-224 | [CAS]
649749-10-0 | [Synonyms]
ATN-224
WTX-101)
Choline tetrathiomolybdate
Bis(choline)tetrathioMolybdate
ATN-224
(Choline tetrathiomolybdate
CHOLINE TETRATHIOMOLYBDATE;WTX-101;WTX 101;WTX101
bis(sulfanylidene)molybdenum,2-hydroxyethyl(trimethyl)azanium,sulfanide | [Molecular Formula]
C10H28MoN2O2S4 | [MDL Number]
MFCD25976790 | [MOL File]
649749-10-0.mol | [Molecular Weight]
432.542 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:20.0(Max Conc. mg/mL);46.24(Max Conc. mM)
DMSO:PBS (pH 7.2):0.5(Max Conc. mg/mL);1.16(Max Conc. mM) | [form ]
A crystalline solid | [color ]
Pink to red |
| Hazard Information | Back Directory | [Description]
ATN-224 is a choline salt of tetrathiomolybdate and an inhibitor of superoxide dismutase 1 (SOD1; IC50s = 2.91 and 3.51 μM in human and mouse blood cells, respectively, in vitro).1 ATN-224 reduces the viability of cultured oxidative stress-resistant WEHI7.2 murine thymic lymphoma cells (EC50s = 5-6 nM) and human diffuse large B cell lymphoma cell lines (EC50s = 9.73-105.61 nM) independently of Bcl-2 and Bcl-xL.2,3 In vivo, ATN-224 (0.7 mg/kg) chelates copper to stabilize an antitumor viral vector, enhancing its efficacy against lung metastases in mice.4 It also inhibits angiogenesis in a mouse model (IC50s = 1.50-3 mg/kg via gavage).1 |
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DC Chemicals
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