| Identification | Back Directory | [Name]
Glycogen Phosphorylase Inhibitor | [CAS]
648926-15-2 | [Synonyms]
Glycogen Phosphorylase Inhibitor
2-chloro-4,5-difluoro-N-[[2-methoxy-5-(methylcarbamoylamino)phenyl]carbamoyl]benzamide | [Molecular Formula]
C17H15ClF2N4O4 | [MDL Number]
MFCD22050364 | [MOL File]
648926-15-2.mol | [Molecular Weight]
412.78 |
| Chemical Properties | Back Directory | [density ]
1.490±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF:5.0(Max Conc. mg/mL);12.11(Max Conc. mM)
DMSO:5.0(Max Conc. mg/mL);12.11(Max Conc. mM) | [form ]
White powder solid. | [pka]
8.47±0.46(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Description]
Glycogen phosphorylase in the liver, muscle, and brain initiate glycogenolysis by releasing glucose-1-phosphate from glycogen. Glycogen phosphorylase inhibitor is a cell-permeable acyl urea first identified as an inhibitor of human liver glycogen phosphorylase (IC50 = 53 nM). It blocks glucagon-induced hepatic glycogenolysis in vivo. Glycogen phosphorylase inhibitor has been used to study glycogen utilization in human liver HepG2 cells, retinal explants, and human T lymphocyte Kit 225 cells. | [Uses]
Glycogen Phosphorylase Inhibitor is used in biological studies to evaluate glycogen utilization in human liver HepG2 cells. |
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