| Identification | Back Directory | [Name]
H-ALA-GLN-ASP-PHE-VAL-GLN-TRP-LEU-MET-ASN-THR-OH | [CAS]
64790-15-4 | [Synonyms]
AQDFVQWLMNT
glucagon(19-29
GLUCAGON (19-29), HUMAN
Miniglucagon (huMan, rat, porcine)
Glucagon (19-29) (human, rat, porcine)
GLUCAGON (19-29), BOVINE, HUMAN, PORCINE
PHE-VAL-GLN-TRP-LEU-MET-ASN-THR: FVQWLMNT
GLUCAGON (19-29) (HUMAN, BOVINE, PORCINE)
ALA-GLN-ASP-PHE-VAL-GLN-TRP-LEU-MET-ASN-THR
H-ALA-GLN-ASP-PHE-VAL-GLN-TRP-LEU-MET-ASN-THR-OH
Glucagon (19-29) (huMan, rat, porcine)
Miniglucagon (huMan, rat, porcine)
L-Alanyl-L-glutaminyl-L-a-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine
L-Threonine,L-alanyl-L-glutaminyl-L-a-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-
L-Threonine, L-alanyl-L-glutaminyl-L-α-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl- | [Molecular Formula]
C61H89N15O18S | [MDL Number]
MFCD00076518 | [MOL File]
64790-15-4.mol | [Molecular Weight]
1352.51 |
| Chemical Properties | Back Directory | [Boiling point ]
1828.5±65.0 °C(Predicted) | [density ]
1.339±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C
| [solubility ]
insoluble in EtOH; insoluble in H2O; ≥135.2 mg/mL in DMSO | [form ]
Powder | [pka]
3.19±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
This fragment inhibits calcium activated ATPase activity | [in vivo]
Glucagon (19-29), also named Miniglucagon, is the COOH-terminal (19-29) fragment processed from glucagon. Glucagon (19-29) dose-dependently inhibits insulin secretion stimulated by 8.3 M glucose, with no change in the perfusion flow rate. A concentration of 1 nM Glucagon (19-29) has a significant inhibitory effect on a 1 nM glucagon-like peptide 1 (7-36) amide–potentiated insulin secretion[1]. Glucagon (19-29) is a highly potent and efficient inhibitor of insulin release by closing, via hyperpolarization, voltage-dependent Ca2+ channels linked to a pathway involving a pertussis toxin-sensitive G protein[2]. | [storage]
Store at -20°C |
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