| Identification | Back Directory | [Name]
9ALPHA,11,15S-TRIHYDROXY-THROMBOX-13E-EN-1-OIC ACID | [CAS]
64626-32-0 | [Synonyms]
TXB1
THROMBOXANE B1
JSDWWNLTJCCSAV-VZBVYBAISA-N
9ALPHA,11,15S-TRIHYDROXY-THROMBOX-13E-EN-1-OIC ACID
(13E,15S)-9α,11,15-Trihydroxythrombox-13-en-1-oic acid
2H-Pyran-3-heptanoic acid, tetrahydro-4,6-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]-, (2R,3S,4S)- | [Molecular Formula]
C20H36O6 | [MDL Number]
MFCD08062183 | [MOL File]
64626-32-0.mol | [Molecular Weight]
372.5 |
| Hazard Information | Back Directory | [Description]
Dihomo-γ-linolenic acid (DGLA) is one of the 20-carbon fatty acids that can be metabolized to prostaglandins and thromboxanes (TXs) by cyclooxygenases 1 and 2 (COX-1/COX-2).1 The result of this metabolism in the human platelet yields TXB1. TXB1 is produced in small amounts when DGLA is added to washed suspensions of human platelets, while the major metabolism of this 1-series fatty acid is via 12-lipoxygenase.2 However, when co-incubated with amounts of ethanol often found in intoxicated humans, the metabolism of DGLA shifts to an enhanced production of TXB1.2 Urinary TXB1 or its metabolites may thus be a specific biomarker of prior ethanol abuse. | [Definition]
ChEBI: Thromboxane B1 is a thromboxane B that is thromboxane B2 in which the double bond at position 5-6 has been reduced to a single bond. It is a thromboxanes B and a monocarboxylic acid. | [References]
1. Levin, G., Duffin, K.L., Obukowicz, M.G., et al. Differential metabolism of dihomo-γ-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: Implications for cellular synthesis of prostaglandin E1 and prostaglandin E2 Biochem. J. 365(Pt 2),489-496(2002).
2. Manku, M.S., Oka, M., and Horrobin, D.F. Differential regulation of the formation of prostaglandins and related substances from arachidonic acid and from dihomogammalinolenic acid. I. Effects of ethanol Prostaglandins Med. 3(2),119-128(1979). |
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