| Identification | Back Directory | [Name]
2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile | [CAS]
642008-81-9 | [Synonyms]
BRD6989
BRD6989
(BRD-6989
BRD6989 >=98% (HPLC)
2-Amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile
2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile | [Molecular Formula]
C16H16N4 | [MDL Number]
MFCD04013193 | [MOL File]
642008-81-9.mol | [Molecular Weight]
264.33 |
| Hazard Information | Back Directory | [Uses]
BRD 6989, is a small molecule inhibitor with high selectivity for CDK8 over CDK19. Increases IL-10 production in stimulated human and murine macrophages and dendritic cells. | [Definition]
ChEBI: 2-amino-6-methyl-4-(3-pyridinyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile is a member of bipyridines. | [Biological Activity]
BRD6989 is an inhibitor of cyclin-dependent kinase 8 (CDK8) th at upregulates production of interleukin-10 (IL-10). BRD6989 was shown to bind cyclin C–CDK8 complex selectively with an IC50 value ∼200 nM and to inhibit the kinase activity of recombinant cyclin C–CDK8 or cyclin C–CDK19 complexes with IC50 values ∼500 nM and >30 μMrespectively. It enhanced the production interleukin-10 (IL-10) enhances IL-10 production in activated human and murine macrophages and dendritic cells with an EC50 value ∼1 μM. | [storage]
Store at +4°C |
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BOC Sciences
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DC Chemicals
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Energy Chemical
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