| Identification | Back Directory | [Name]
SIB 1893 | [CAS]
6266-99-5 | [Synonyms]
SIB 1893
NSC 36665
(E/Z)-SIB-1893
(E)-2-METHYL-6-STYRYL-PYRIDINE
2-METHYL-6-(2-PHENYLETHENYL)PYRIDINE
(E)-2-METHYL-6-(2-PHENYLETHYL)-PYRIDINE
Pyridine, 2-methyl-6-(2-phenylethenyl)-
2-Methyl-6-[(E)-2-phenylethenyl]pyridine | [Molecular Formula]
C14H13N | [MDL Number]
MFCD02262120 | [MOL File]
6266-99-5.mol | [Molecular Weight]
195.26 |
| Hazard Information | Back Directory | [Uses]
SIB 1893 is a selective antagonist of mGluR-5. SIB 1893 acts as a positive allosteric modulator of human metabotropic mGlu4 (1). Anticonvulsant (2). | [Definition]
ChEBI: 2-methyl-6-(2-phenylethenyl)pyridine is a member of styrenes. | [Biological Activity]
A highly selective non-competitive antagonist for the metabotropic glutamate mGlu 5 receptor subtype; displays an IC 50 value of 0.3 μ M? at hmGlu 5 , compared with > 100 μ M at hmGlu 1b , hmGlu 2 , hmGlu 6 , hmGlu 7 and hmGlu 8 . Centrally active upon systemic administration in vivo . Positive allosteric modulator at mGlu 4 receptors. | [in vivo]
(E)-SIB-1893 produces hypothermia in freely moving rats in a dose-dependent manner[1]. |
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