| Identification | Back Directory | [Name]
MK-0812 | [CAS]
624733-88-6 | [Synonyms]
CS-206
MK-0812
MK0812(BASE)
MK0812,MK-0812
1,5-anhydro-2,3-dideoxy-3-(((1r,3s)-3-((7,8-dihydro-3-(trifl...
1,5-Anhydro-2,3-dideoxy-3-[[(1R,3S)-3-[[7,8-dihydro-3-(trifluoromethyl)-1,6-naphthyridin-6(5H)-yl]carbonyl]-3-(1-methylethyl)cyclopentyl]am
[(1S,3R)-3-[[(3S,4S)-3-methoxyoxan-4-yl]amino]-1-propan-2-ylcyclopentyl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
1,5-Anhydro-2,3-dideoxy-3-[[(1R,3S)-3-[[7,8-dihydro-3-(trifluoromethyl)-1,6-naphthyridin-6(5H)-yl]carbonyl]-3-(1-methylethyl)cyclopentyl]amino]-4-O-methyl-D-erythro-pentitol
D-erythro-Pentitol, 1,5-anhydro-2,3-dideoxy-3-[[(1R,3S)-3-[[7,8-dihydro-3-(trifluoromethyl)-1,6-naphthyridin-6(5H)-yl]carbonyl]-3-(1-methylethyl)cyclopentyl]amino]-4-O-methyl- | [Molecular Formula]
C24H34F3N3O3 | [MDL Number]
MFCD11977737 | [MOL File]
624733-88-6.mol | [Molecular Weight]
469.54 |
| Chemical Properties | Back Directory | [Boiling point ]
562.0±50.0 °C(Predicted) | [density ]
1.24 | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
8.51±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
MK-0812 is a potent C-C chemokine receptor type 2 (CCR2) antagonist. | [in vivo]
MK-0812 is administered by continuous i.v. infusion to maintain a constant level of the drug in blood[1]. Administration of MK0812 at 30 mg/kg, p.o. reduces the frequency of Ly6G-Ly6Chi monocytes in the peripheral blood, while no impact on circulating Ly6G+Ly6C+ neutrophil frequency is observed. In addition, MK0812 treatment causes a dose-dependent reduction in circulating Ly6Chi monocytes and a corresponding elevation in the CCR2 ligand CCL2[2]. | [IC 50]
CCR2 | [storage]
Store at -20°C |
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