| Identification | Back Directory | [Name]
EPIDERMAL GROWTH FACTOR, HUMAN | [CAS]
62229-50-9 | [Synonyms]
EGP
URG
MUC9
HEGF
RHEGF
OVGP1
CHIT5
kutrol
Mucin 9
LONG EGF
HUMAN EGF
HUMAN URG
Anthelone
urogastron
antheloneu
EGF, HUMAN
uro-gastron
urogastrone
uroenterone
uroanthelone
LONG EGF human
REC EGF (HUMAN)
HUMAN UROGASTRONE
LONGEGF MEDIA GRADE
EGF from mouse
RECOMBINANT HUMAN EGF
Oviductal glycoprotein
EGF, Human, Recombinant,
LONG(TM) EGF, MEDIA GRADE
epidermalgrowthfactor(egf)
Epidemal growth factor(EGF)
Epidermal cell growth factor
EPIDERMAL GROWTH FACTOR 95+%
LONG EGF, RECOMBINANT ANALOG
HUMAN EPIDERMAL GROWTH FACTOR
EPIDERMAL GROWTH FACTOR, HUMAN
Epidermal Growth Factor(rh-EGF)
epidermalgrowthfactor-urogastrone
mouse epidermal growth factor (egf)
EPIDERMAL GROWTH FACTOR (EGF) HUMAN
REC EPIDERMAL GROWTH FACTOR (HUMAN)
EGF, Epidermal cell growth factor
urogastrone from human pregnancy urine
EPIDERMAL GROWTH FACTOR 98+%, LYOPHILIZED
EPIDERMAL GROWTH FACTOR, HUMAN, RECOMBINANT
epidermalgrowthfactorreceptorgrade*frommouse
Epidemal Growth Factor Human from Mouse
EPIDERMAL GROWTH FACTOR HUMAN, RECOMBINANT 98+%
EGF (Recombinant Human Epidermal Growth Factor)
EGF, Murine Submaxillary Glands, Receptor Grade
EPIDERMAL GROWTH FACTOR FROM MOUSE*SUBMA XILLARY GLA
EPIDERMAL GROWTH FACTOR FROM RAT SUBMANDIBULAR GLANDS
EPIDERMAL GROWTH FACTOR (FROM MOUSE SUBMAXILLARY GLAND) 95%
Epidermal Growth Factor, Murine Submaxillary Glands, Recpt.
Epidermal Growth Factor from murine submaxillary gland
Epidermal Growth Factor from murine submaxillary gland,EGF, Epidermal cell growth factor
ASN-SER-ASP-SER-GLU-CYS-PRO-LEU-SER-HIS-ASP-GLY-TYR-CYS-LEU-HIS-ASP-GLY-VAL-CYS-MET-TYR-ILE-GLU-ALA-LEU-ASP-LYS-TYR-ALA-CYS-ASN-CYS-VAL-VAL-GLY-TYR-ILE-GLY-GLU-ARG-CYS-GLN-TYR-ARG-ASP-LEU-LYS-TRP-TRP-GLU-LEU-ARG | [EINECS(EC#)]
263-468-7 | [Molecular Formula]
NULL | [MDL Number]
MFCD00132565 | [MOL File]
62229-50-9.mol | [Molecular Weight]
6045.67 |
| Hazard Information | Back Directory | [Description]
Epidermal growth factor (EGF) is a polypeptide ligand for the EGF receptor (EGFR; Item No. 32026).1,2 It is synthesized as a 1,217 amino acid glycosylated transmembrane precursor protein from which mature, soluble EGF is formed by proteolysis. Mature EGF is a 53-amino acid polypeptide that contains six cysteine residues, which form three intramolecular disulfide bonds essential to the biological activity of EGF. EGF is synthesized in the brain, kidney, pancreas, small intestine, pituitary gland, and submaxillary gland and is found in various bodily fluids, including saliva, cerebrospinal fluid, blood, breast milk, and prostatic fluid.2 Binding of EGF to the EGFR induces receptor dimerization, autophosphorylation, and intracellular signaling with roles in cell proliferation. In patients with early Parkinson’s disease and Alzheimer’s disease with amnestic mild cognitive impairment, low plasma EGF levels are predictive of future long-term cognitive decline.3 Plasma levels of EGF are reduced in pregnant woman infected with T. cruzi compared with uninfected pregnant controls.4 Exogenous application of EGF normalizes cortical GABAergic transmission and improves rotarod performance in the R6/2 transgenic mouse model of Huntington''s disease.5 Probiotic administration of E. coli engineered to secrete human EGF induces epithelial barrier restoration in a mouse model of intestinal ulcers.6 Immunization with human EGF induces an anti-EGF antibody response and increased survival in mice with EGFR-expressing tumors.7 Cayman''s EGF (human, recombinant) protein can be used for cell-based assay applications. This protein consists of 54 amino acids and has a calculated molecular mass of 6.3 kDa. | [Uses]
Epidermal Growth Factor (EGF) from murine submaxillary gland has been used as a mitogen, triggering the cell to commence mitosis, in a variety of cell lines. In tissue cultures, EGF acts to reduce or eliminate the requirement for serum and can be used in conjunction with other media additives and hormone. The working concentration for EGF is generally 0.1-10 ng/mL. | [General Description]
EGF (epidermal growth factor) is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells. Recombinant murine EGF is a 6kDa globular protein containing 53 amino acid residues, including 3 intramolecular disulfide-bonds. | [Biochem/physiol Actions]
EGF (epidermal growth factor) has been shown to inhibit gastric secretion, and to be involved in wound healing. EGF signals through a receptor known as c-erbB, which is a class I tyrosine kinase receptor. This receptor also binds with TGF (transforming growth factor)-α and VGF (vaccinia virus growth factor). EGF plays an important role in embryogenesis and cardiogenesis. |
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