| Identification | Back Directory | [Name]
8-hydroxyloxapine | [CAS]
61443-77-4 | [Synonyms]
8-hydroxyloxapine
Loxapine 8-Hydroxy Impurity
2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol
8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol
Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)- | [Molecular Formula]
C18H18ClN3O2 | [MOL File]
61443-77-4.mol | [Molecular Weight]
343.81 |
| Chemical Properties | Back Directory | [Melting point ]
212-215°C | [storage temp. ]
Amber Vial, -20°C Freezer, Under Inert Atmosphere | [solubility ]
DMSO: soluble | [form ]
A solid | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Description]
8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α1-adrenergic receptors (Ki values = 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A-adrenergic receptors, respectively). It reduces agitation associated with schizophrenia or bipolar disorder. 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [14C]5-HT uptake in vitro (IC50 = 2 μM in human platelets). | [Chemical Properties]
Pale Yellow Solid | [Uses]
The inactive | [storage]
Store at -20°C |
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