| Identification | Back Directory | [Name]
WUWEIZISU C | [CAS]
61301-33-5 | [Synonyms]
WUWEIZISU C
,8-dimethyl-
SCHIZANDRIN C
WUWEIZISU C USP/EP/BP
(S)-(-)-Schisandrin C
Schisandrin C >=98% (HPLC)
Schisandrin C (Schizandrin-C
Schisandrin C
(S)-(-)-Schisandrin C
cycloocta(1,2-f:3,4-f’)bis(1,3)benzodioxole6,7,8,9-tetrahydro-1,13-dimethoxy-7
(6R,7S,13aS)-5,6,7,8-Tetrahydro-13,14-dimethoxy-6,7-dimethylcycloocta[1,2-f:3,4-f']bis[1,3]benzodioxole
Cycloocta[1,2-f:3,4-f']bis[1,3]benzodioxole, 5,6,7,8-tetrahydro-13,14-dimethoxy-6,7-dimethyl-, (6R,7S,13aS)- | [Molecular Formula]
C22H24O6 | [MDL Number]
MFCD00272170 | [MOL File]
61301-33-5.mol | [Molecular Weight]
384.42 |
| Chemical Properties | Back Directory | [Melting point ]
122-123℃ | [Boiling point ]
549.2±50.0 °C(Predicted) | [density ]
1.232 | [storage temp. ]
2-8°C | [solubility ]
DMSO : 8.33 mg/mL (21.67 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) | [form ]
powder | [color ]
White | [LogP]
5.623 (est) |
| Hazard Information | Back Directory | [Description]
Schisandrin C is a lignan originally isolated from Schizandrae that has diverse biological activities.1,2,3,4,5 It decreases viability of U937 cells in a concentration-dependent manner and induces cell cycle arrest at the G1 phase when used at a concentration of 100 μM.2 Schisandrin C (5-20 μM) decreases hydrogen peroxide-induced cell death and production of reactive oxygen species (ROS) in C2C12 skeletal muscle cells.3 It also decreases levels of matrix metalloproteinase-2 (MMP-2), MMP-9, COX-2, VCAM-1, IL-1β, and TNF-α in hydrogen peroxide-stimulated C2C12 cells. Schisandrin C decreases lipoteichoic acid-induced production of nitric oxide (NO), prostaglandin E2 (PGE2; Item No. 14010), TNF-α, IL-1β, and IL-6 in mouse primary microglia.4 In vivo, schisandrin C (200 mg/kg) decreases serum alanine amino transferase (ALT) and aspartate amino transferase (AST) activity, increases hepatic mitochondrial and total glutathione (GSH) levels, and reduces liver injury in a mouse model of acetaminophen-induced liver injury partially via inhibition of the cytochrome P450 (CYP) isoforms CYP2E1, CYP1A2, and CYP3A11.5 | [Uses]
Schisandrin C potently inhibits proprotein convertase subtillsin-kexin type 9 (PCSK9) mRNA expression. Also, it displays strong protective effects in SH-SY5Y cells against serum and glucose deprivation (SGD) injury. |
|
|