| Identification | Back Directory | [Name]
2-HEXADECANOYLTHIO-1-ETHYLPHOSPHORYLCHOLINE | [CAS]
60793-01-3 | [Synonyms]
HEPC
thioglycollecithin
BDPQVGIMLZYZQA-UHFFFAOYSA-N
2-HEXADECANOYLTHIO-1-ETHYLPHOSPHORYLCHOLINE
4-OXIDE-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-3,5-DIOXA-8-THIA-4-PHOSPHATETRACOSAN-1-AMINIUM, INNER SALT | [Molecular Formula]
C23H48NO5PS | [MDL Number]
MFCD08059578 | [MOL File]
60793-01-3.mol | [Molecular Weight]
481.67 |
| Hazard Information | Back Directory | [Description]
Thioester analogs of glycerophospholipids, in combination with Ellman’s reagent, are convenient colorimetric substrates for the measurement of phospholipase activity. HEPC is a truncated analog of phosphatidylcholine with the entire sn-1 substituent deleted, and with a hexadecylthioester in the sn-2 position.1 HEPC is a substrate for Type II phospholipase A2 (PLA2) enzymes, such as porcine pancreatic, bee venom, and snake venom PLA2. The intrinsic biological activity of HEPC has not been actively investigated. | [Definition]
ChEBI: 2-hexadecanoylthio-1-ethylphosphorylcholine is a member of phosphocholines. | [References]
1. Bhat, M.K., Mueller-Harvey, I., Sumner, I.G., et al. Simplified methods for the synthesis of 2-hexadecanoylthio-1-ethylphosphorylcholine and for the determination of phospholipase A2 activity Biochim. Biophys. Acta 1166,244-250(1993). |
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