| Identification | Back Directory | [Name]
PROSTAGLANDIN J2 | [CAS]
60203-57-8 | [Synonyms]
PGJ2
Aids058772
Aids-058772
PROSTAGLANDIN J2
PGJ2 (Prostaglandin J2)
Prostaglandin J2 (PGJ2)
9-deoxy-delta-9-prostaglandind2
Prostaglandin J2 Lipid Maps MS Standard
PROSTAGLANDIN J2, 5MG/ML IN METHYL ACETA
11-OXO-15S-HYDROXY-PROSTA-5Z,9,13E-TRIEN-1-OIC ACID
(5Z,13E,15S)-15-HYDROXY-11-OXOPROSTA-5,9,13-TRIEN-1-OIC ACID
(5Z,13E,15S)-15-Hydroxy-11-oxoprosta-5,9,13-triene-1-oic acid
Prosta-5,9,13-trien-1-oic acid, 15-hydroxy-11-oxo-, (5Z,13E,15S)-
(Z)-7-[(1S,5R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-4-oxo-1-cyclopent-2-enyl]hept-5-enoic acid | [EINECS(EC#)]
201-185-2 | [Molecular Formula]
C20H30O4 | [MDL Number]
MFCD00065804 | [MOL File]
60203-57-8.mol | [Molecular Weight]
334.45 |
| Chemical Properties | Back Directory | [Boiling point ]
521.7±50.0 °C(Predicted) | [density ]
1.103±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
DMF: >100 mg/ml (from PGD2); DMSO: >50 mg/ml (from PGD2); Ethanol: >75 mg/ml (from PGD2); PBS pH 7.2: >2.7 mg/ml (from 15-deoxy-.DEL | [form ]
Liquid | [pka]
4.75±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Prostaglandin J2 (PGJ2) is formed from PGD2 by the elimination of the C-9 hydroxyl group, a process which is accelerated by the presence of albumin. PGJ2 inhibits platelet aggregation with an IC50 of about 5-10 nM. PGJ2 has antimitotic and antiproliferative effects on a variety of cultured normal cells and tumor cell lines. However, this activity has been attributed to further metabolites of PGJ2 and not the parent compound itself. | [Uses]
PGJ2 (Prostaglandin J2) is a Prostaglandin D2 metabolite that has shown potent anti-neoplastic and antiviral activity. | [Definition]
ChEBI: A member of the class of prostaglandins J that consists of prosta-5,9,13-trien-1-oic acid substituted by an oxo group at position 11 and a hydroxy group at position 15 (the 5Z,13E,15S stereoisomer). |
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