| Identification | Back Directory | [Name]
LAUROLITSINE | [CAS]
5890-18-6 | [Synonyms]
Norboldine
Aids161652
Aids-161652
Laurolistine
Laurolitsine
Norisoboidine
1,10-Dimethoxy-6aα-noraporphine-2,9-diol
(S)-5,6,6a,7-Tetrahydro-1,10-dimethoxy-4H-dibenzo[de,g]quinoline-2,9-diol
(6aS)-5,6,6a,7-Tetrahydro-1,10-dimethoxy-4H-dibenzo[de,g]quinoline-2,9-diol
4H-Dibenzo[de,G]quinoline-2,9-diol, 5,6,6A,7-tetrahydro-1,10-dimethoxy-, (6as)- | [Molecular Formula]
C18H19NO4 | [MDL Number]
MFCD06809897 | [MOL File]
5890-18-6.mol | [Molecular Weight]
313.351 |
| Chemical Properties | Back Directory | [Melting point ]
138-140 ºC | [Boiling point ]
453.15°C (rough estimate) | [density ]
1.313 | [refractive index ]
1.5100 (estimate) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Cryst. | [pka]
9.81±0.20(Predicted) | [color ]
Off-white to pink |
| Hazard Information | Back Directory | [Description]
This noraporphiae alkaloid has been obtained from Litsea japonica and Neolitsea
sericea and swells at 11 5-8°C before melting. It is dextrorotatory with [o:lbl +
102.5° (EtOH) and yields a picrate as yellow needles, m.p. 212°C (dec.) and a
picrolonate, m.p. 239°C (dec.). The N-methyl derivative is identical with boldine. | [Uses]
Laurolitsine is an alkaloid extracted from Polyalthia longifolia var. pendula. | [Definition]
ChEBI: An isoquinoline alkaloid that is noraporphine substituted by hydroxy groups at positions 2 and 9 and methoxy groups at positions 1 and 10. Isolated from Litsea glutinosa and Lindera chunii, exhibits inhibitory activity against HIV
1 integrase. | [References]
Nakasato, Nomura., Chem. Pharm. Bull., (Tokyo), 7, 780 (1959)
Kozuka., J. Ph arm. Soc., Japan, 82, 1567 (1962)
See also:
Johns, Lamberton., Austral. J. Chem., 20, 1277 (1967) |
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