| Identification | Back Directory | [Name]
GW806742X | [CAS]
579515-63-2 | [Synonyms]
CS-2659
GW806742X
GW806742X ≥95%
GW806742X >=98% (HPLC)
GW806742X;GW-806742X;GW 806742X
1-[4-[methyl-[2-(3-sulfamoylanilino)pyrimidin-4-yl]amino]phenyl]-3-[4-(trifluoromethoxy)phenyl]urea
Benzenesulfonamide, 3-[[4-[methyl[4-[[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]phenyl]amino]-2-pyrimidinyl]amino]- | [Molecular Formula]
C25H22F3N7O4S | [MDL Number]
MFCD29036385 | [MOL File]
579515-63-2.mol | [Molecular Weight]
573.55 |
| Chemical Properties | Back Directory | [density ]
1.524±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:100.0(Max Conc. mg/mL);174.35(Max Conc. mM) | [form ]
Solid | [pka]
10.09±0.60(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
GW806742X, an ATP mimetic, is a potent MLKL inhibitor that binds the MLKL pseudokinase domain with a Kd of 9.3μM. It has anti-VEGFR2 activity (IC50=2 nM). It delays MLKL membrane translocation and inhibits necrosis. | [in vitro]
GW806742X (0.1-10000 nM) inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ (1 ng/mL TNF, 500 nM compound A (Smac mimetic), 10 μM Q-VD -OPh) in a dose-dependent manner. GW806742X shows inhibition of VEGF induced proliferation of HUVECs with an IC50 of 5 nM. | [target]
| MLKL 9.3 μM (Kd) | VEGFR2 2 nM (IC 50 < /sub> ) | | [storage]
Store at -20°C |
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| Company Name: |
Lynnchem
|
| Tel: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
|