| Identification | Back Directory | [Name]
BRL 54443 | [CAS]
57477-39-1 | [Synonyms]
CS-1781
BRL 54443
BRL 54443 HCl
BRL 54443, >=98%
BRL-54443;BRL54443
BRL 54443 USP/EP/BP
BRL54443;BRL 54443;BRL-54443
3-(1-methylpiperidin-4-yl)-1H-indol-5-ol
3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol
1H-Indol-5-ol, 3-(1-Methyl-4-piperidinyl)-
5-HYDROXY-3-(1-METHYLPIPERIDIN-4-YL)-1H-INDOLE
3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol BRL 54443 | [Molecular Formula]
C14H18N2O | [MDL Number]
MFCD01861184 | [MOL File]
57477-39-1.mol | [Molecular Weight]
230.31 |
| Chemical Properties | Back Directory | [Boiling point ]
431.5±45.0 °C(Predicted) | [density ]
1.196 | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
H2O: 50 mg/mL
| [form ]
solid
| [pka]
10.08±0.40(Predicted) | [color ]
white
|
| Hazard Information | Back Directory | [Uses]
BRL-53443 is a potent 5-HT and dopamine receptor agonist. Neuroresearch product. | [Definition]
ChEBI: 3-(1-methyl-4-piperidinyl)-1H-indol-5-ol is a member of hydroxyindoles. | [Biological Activity]
A potent 5-ht 1E/1F receptor agonist (pEC 50 values are 8.5 and 8.6 respectively). Displays > 30-fold selectivity over other 5-HT and dopamine receptors (pK i values are 8.7. 8.9, 7.2, 6.9, 7.2, 5.9, 7.0, 6.5, < 6, < 6, 6.3 and 6.2 for human 5-HT 1E , 1F , 1A , 1B , 1D , 2A , 2B , 2C , 4 , 7 , D 2 and D 3 receptors respectively). Induces 5-HT 2A receptor-mediated mouse aortic contraction in vitro (pEC 50 = 6.52). Active in vivo . | [storage]
Store at -20°C | [References]
1. a.m. brown, k. avenell, t j. young et al. brl 54443, a potent agonist with selectivity for human cloned 5-ht1e and 5-ht1f receptors. 1998. br.j.pharmacol. 123 233p.2. s. lightowler, t. stean, n. upton et al. effect of brl 54443 (3-(1-methylpiperidin-4-yl)-1h-indol-5-ol), a 5-ht1e/1f receptor agonist, on general behaviour and maximal electroshock seizure threshold in the rat. 1998. br.j.pharmacol. 123 237p.3. mckune cm, watts sw. characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway coupling. j pharmacol exp ther. 2001 apr;297(1):88-95.4. janssen p, tack j, sifrim d et al. influence of 5-ht1 receptor agonists on feline stomach relaxation. eur j pharmacol. 2004 may 25;492(2-3):259-67. |
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