| Identification | Back Directory | [Name]
RESORUFIN ETHYL ETHER | [CAS]
5725-91-7 | [Synonyms]
7-ER
ETHOXYRESORUFIN
O7-ETHYLRESORUFIN
7-ETHOXYRESORUFIN
7-Ethoxy Rresorufin
7-Ethoxyphenoxazone
RESORUFIN ETHYL ESTER
RESORUFIN ETHYL ETHER
7-ethoxyphenoxazin-3-one
7-ETHOXY-3H-PHENOXAZIN-3-ONE
3H-Phenoxazin-3-one, 7-ethoxy-
O(7)-ETHYLRESORUFIN, FOR FLUOR-
O(7)-ETHYLRESORUFIN FOR FLUORESCENCE
ETHOXYRESORUFIN [RESORUFIN ETHYL ETHER]
7-Ethoxy-3H-phenoxazin-3-one, Resorufin Ethyl Ester
7-Ethoxy-3H-phenoxazin-3-one, Ethoxyresorufin, O7-Ethylresorufin
Resorufin ethyl ether,7-Ethoxy-3H-phenoxazin-3-one, Ethoxyresorufin, O7-Ethylresorufin | [Molecular Formula]
C14H11NO3 | [MDL Number]
MFCD00037661 | [MOL File]
5725-91-7.mol | [Molecular Weight]
241.24 |
| Chemical Properties | Back Directory | [Appearance]
Red Solid | [Melting point ]
223-225 °C(lit.)
| [Boiling point ]
389.3±42.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
DMF: soluble
| [form ]
Brown solid. | [pka]
1.43±0.20(Predicted) | [color ]
Dark Orange to Red | [BRN ]
225973 |
| Hazard Information | Back Directory | [Chemical Properties]
Red Solid | [Uses]
A fluorimetric substrate for cytochrome P450 IAI. Inhibits vasorelaxant responses to acetylcholine | [Uses]
Dealkylase substrate for the microfluorimetric analysis of microsomal cytochrome P-450. | [Definition]
ChEBI: 7-ethoxyresorufin is a phenoxazine. | [General Description]
Resorufin ethers are used as markers or substrates for different cytochrome P (CYP) isoforms. Resorufin ethyl ether is the preferred resorufin ether to be metabolized by microsomes of 3-methylcholanthrene treated animals. | [Biological Activity]
cytochrome p450, family 1, subfamily a, polypeptide 1 is a protein that is encoded by human cyp1a1 gene. the protein is a member of the cytochrome p450 superfamily of enzymes. cyp1a1 is involved in phase i xenobiotic and drug metabolism. cyp1a1 is inhibited by fluoroquinolones and macrolides and induced by aromatic hydrocarbons. 7-ethoxyresorufin is a specific subtrate of cyp1a. | [in vitro]
7-ethoxyresorufin (2-10 microm), a substrate for cytochrome p450, which binds to the heme moiety of the enzyme, reduced responses to acetylcholine concentration-dependently but not the other agonists indicating an effect on nitric oxide synthesis although neither affected the conversion of l-arginine to l-citrulline [1]. | [in vivo]
activities of cyp1a (7-ethoxyresorufin) in the liver was determined for comparative purposes. in mice, lps depressed cyp2a5 at low doses but not at doses that increased pro-inflammatory cytokines and no serum levels, and depressed cyp1a activity. blockade of proinflammatory cytokines extended down-regulation of cyp2a5 while not affecting lps-induced depression of cyp1a [2]. | [storage]
Store at -20°C | [References]
[1] oyekan ao, mcgiff jc, rosencrantz-weiss p, quilley j. relaxant responses of rabbit aorta: influence of cytochrome p450 inhibitors. j pharmacol exp ther. 1994 jan;268(1):262-9.
[2] de-oliveira ac, po?a ks, totino pr, paumgartten fj. modulation of cytochrome p450 2a5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship. plos one. 2015 jan 30;10(1):e0117842.
[3] pelkonen o, pasanen m, kuha h, gachalyi b, kairaluoma m, sotaniemi ea, park ss, friedman fk, gelboin hv. the effect of cigarette smoking on 7-ethoxyresorufin o-deethylase and other monooxygenase activities in human liver: analyses with monoclonal antibodies. br j clin pharmacol. 1986 aug;22(2):125-34. |
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