| Identification | Back Directory | [Name]
2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE | [CAS]
56741-95-8 | [Synonyms]
U-54461
U 54461S
PNU-54461
NSC 149027
bropirimine
5-BroMo-6-phenylisocytosine
2-AMino-5-broMo-6-phenyl-4-pyriMidinol
2-Amino-5-bromo-6-phenylpyrimidin-4-ol
2-AMino-5-broMo-6-phenyl-4-pyriMidinone
2-Amino-5-bromo-6-phenyl-4(3H)-pyrimidone
2-amino-5-bromo-6-phenyl-4(1h)-pyrimidinon
2-amino-5-bromo-6-phenyl-4(1h)-pyrimidinone
2-amino-5-bromo-6-phenyl-1H-pyrimidin-4-one
2-AMino-5-broMo-6-phenyl-4(3H)-pyriMidinone
2-Amino-5-bromo-6-phenylpyrimidin-4(1H)-one
2-Amino-5-bromo-6-phenylpyrimidin-4(3H)-one
2-AMINO-4-HYDROXY-5-BROMO-6-PHENYLPYRIMIDINE
2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE
2-Amino-5-bromo-4-phenyl-6-hydroxypyrimidine
4(3H)-PyriMidinone, 2-aMino-5-broMo-6-phenyl-
2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE USP/EP/BP
5-Bromo-6-phenyl-2,3-dihydro-2-iminopyrimidin-4(1H)-one
5-BroMo-2,3-dihydro-2-iMino-6-phenyl-4(1H)-pyriMidinone | [Molecular Formula]
C10H8BrN3O | [MDL Number]
MFCD00813905 | [MOL File]
56741-95-8.mol | [Molecular Weight]
266.09 |
| Chemical Properties | Back Directory | [Melting point ]
285-287° (Stevens); mp 246-248° (Brown, Stevens) | [Boiling point ]
389.7±52.0 °C(Predicted) | [density ]
1.6292 (rough estimate) | [refractive index ]
1.6520 (estimate) | [storage temp. ]
room temp | [solubility ]
DMSO: ≥5mg/mL (warm DMSO) | [form ]
powder | [pka]
3.18; 8.53(at 25℃) | [color ]
white to beige | [Water Solubility ]
7.8mg/L(37 ºC) |
| Hazard Information | Back Directory | [Description]
Bropirimine is an immunomodulator with diverse biological activities. It is a toll-like receptor 7 (TLR7) agonist that inhibits RANKL-induced osteoclast differentiation of murine bone marrow-derived macrophages (BMDMs) in a concentration-dependent manner, an effect that is reversed by an anti-IFN-β antibody. Dietary administration of bropirimine (200 mg/kg twice per week) prevents development of transitional cell carcinomas (TCCs) in a mouse model of carcinogen-induced bladder carcinoma. Bropirimine (100 mg/kg) reduces pulmonary collagen accumulation and bronchoalveolar lavage fluid (BALF) monocyte and eosinophil infiltration in a hamster model of bleomycin-induced lung fibrosis. It also delays disease onset and progression and increases plasma IFN levels in a mouse model of experimental autoimmune encephalomyelitis (EAE). | [Uses]
Bropirimine is an orally active immunostimulant; anticancer agent. Bropirimine is an interferon inducer that is a potentially useful in the the treatment of superficial bladder cancer (transitional cell carcinoma). Studies suggest that Bropirimine has direct antitumor activity rather than a cytokine-mediated antitumor effect. | [Definition]
ChEBI: Bropirimine is a member of pyrimidines. | [Biochem/physiol Actions]
Bropirimine is an immunostimulating agent. The compound induces production of α and β interferons and enhances NK cell function. Bropirimine has antiproliferative effects in cancer cell lines and tumor growth in in vivo models. | [storage]
Desiccate at RT | [Toxics Screening Level]
The initial threshold screening level (ITSL) for bropirimine is 15 μg/m3
based
on an annual averaging time. |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
|