| Identification | Back Directory | [Name]
cholesta-3,5-dien-7-one | [CAS]
567-72-6 | [Synonyms]
cholesta-3,5-dien-7-one
7-Ketocholesta-3,5-diene
Cholesta-3,5-diene-7-one-d7 | [EINECS(EC#)]
209-305-5 | [Molecular Formula]
C27H42O | [MDL Number]
MFCD00184936 | [MOL File]
567-72-6.mol | [Molecular Weight]
382.62 |
| Chemical Properties | Back Directory | [Melting point ]
114 °C | [Boiling point ]
494.0±12.0 °C(Predicted) | [density ]
0.99±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Chloroform: 10 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Uses]
Delta3,5-cholestadien-7-one is an oxysterol and a negative allosteric modulator of GABAA receptors. Delta3,5-cholestadien-7-one reduces GABA-induced currents in HEK cells expressing α1β1γ2 or α4β3γ2 subunit-containing GABAA receptors with IC50 values of 1.5 and 1 μM, respectively. Delta3,5-cholestadien-7-one reduces GABA-induced depolarization of peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse dorsal root ganglion (DRG) neurons[1][2]. | [References]
[1] Hahn M, et al. Cholest-3,5-dien-7-one formation in peroxidized human plasma as an indicator of lipoprotein cholesterol peroxidation potential. Biochim Biophys Acta. 1995 Apr 6;1255(3):341-3. DOI:10.1016/0005-2760(95)00004-v |
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