| Identification | Back Directory | [Name]
altertoxin I | [CAS]
56258-32-3 | [Synonyms]
SCA1
ATXN1
ATX-1
D6S504E
altertoxin I
Altertoxin l
Dihydroalterperylenol
Spinocerebellar ataxia type 1 protein
Spinocerebellar ataxia type 1 protein homolog
Anti-Ataxin 1, C-Terminal antibody produced in rabbit
(1S)-1,2,11,12,12a,12bβ-Hexahydro-1β,4,9,12aα-tetrahydroxy-3,10-perylenedione
3,10-Perylenedione, 1,2,11,12,12a,12b-hexahydro-1,4,9,12a-tetrahydroxy-, (1S,12aR,12bS)- | [Molecular Formula]
C20H16O6 | [MDL Number]
MFCD02262560 | [MOL File]
56258-32-3.mol | [Molecular Weight]
352.34 |
| Chemical Properties | Back Directory | [Boiling point ]
699.8±55.0 °C(Predicted) | [density ]
1.694±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Dichloromethane: 10 mg/ml | [form ]
A powder | [pka]
7.54±0.60(Predicted) | [biological source]
rabbit |
| Hazard Information | Back Directory | [Uses]
Altertoxin I (Dihydroalterperylenol) is a quinone-type mycotoxin produced by Alternaria alternata fungi, which is mutagenic and cytotoxic, and can weakly disrupts metabolic communication[1]. | [References]
[1] Jarolim K, et al. Activation of the Nrf2-ARE pathway by the Alternaria alternata mycotoxins altertoxin I and II. Arch Toxicol. 2017 Jan;91(1):203-216. DOI:10.1007/s00204-016-1726-7
[2] Boutin BK, et al. Effects of purified altertoxins I, II, and III in the metabolic communication V79 system. J Toxicol Environ Health. 1989;26(1):75-81. DOI:10.1080/15287398909531234
[3] Stack ME, et al. Mutagenicity of the Alternaria metabolites altertoxins I, II, and III. Appl Environ Microbiol. 1986 Oct;52(4):718-22. DOI:10.1128/aem.52.4.718-722.1986 |
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