| Identification | Back Directory | [Name]
10β,17β-dihydroxyestra-1,4-dien-3-one | [CAS]
549-02-0 | [Synonyms]
DHED
10β,17β-dihydroxyestra-1,4-dien-3-one
10,17β-Dihydroxy-estra-1,4-dien-3-one
Estra-1,4-dien-3-one, 10,17-dihydroxy-, (17β)- | [Molecular Formula]
C18H24O3 | [MOL File]
549-02-0.mol | [Molecular Weight]
288.38 |
| Chemical Properties | Back Directory | [Melting point ]
217-219 °C(Solv: ethyl acetate (141-78-6)) | [Boiling point ]
485.3±45.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 10mg/mL, clear | [form ]
powder | [pka]
12.35±0.60(Predicted) | [color ]
white to light brown | [optical activity]
[α]/D -20 to -30°, c = 1 in methanol |
| Hazard Information | Back Directory | [Uses]
DHED has been used to induce an increase of estrogen levels in 3K transgenic mice with Parkinson′s disease (PD)-like motor syndrome. | [Biochem/physiol Actions]
DHED is a substrate for nicotinamide adenine dinucleotide phosphate (NADPH)-dependent dehydrogenase/reductase. Its expression in the brain is correlated to neuroprotection functionality. |
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