| Identification | Back Directory | [Name]
4-bromo-N'-butylbenzohydrazide | [CAS]
537672-41-6 | [Synonyms]
UF 010
CS-2427
UF010, >98%
UF-010; UF 010
UF010 >=98% (HPLC)
4-bromo-N'-butylbenzohydrazide
4-Bromobenzoic acid 2-butylhydrazide
Benzoic acid, 4-bromo-, 2-butylhydrazide | [Molecular Formula]
C11H15BrN2O | [MDL Number]
MFCD03603083 | [MOL File]
537672-41-6.mol | [Molecular Weight]
271.15 |
| Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
insoluble in H2O; ≥10.65 mg/mL in DMSO; ≥20.85 mg/mL in EtOH | [form ]
solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
UF010 is a class I HDAC inhibitor with IC50 values of 0.06, 0.1, 0.5, and 1.5 μM for HDAC3, 2, 1, and 8, respectively. It is more than 6-fold selective for these class I HDACs over any additional HDACs. UF010 is reported to inhibit cancer cell proliferation with a mean GI50 value of 2.94 μM when screened against the NCI-60 panel of cancer cell lines and functions by blocking the G1/S phase of the cell cycle. | [Uses]
4-Bromo-2-butylhydrazide Benzoic Acid inhibits histone deacetylases (HDAC) as potential clinical anticancer therapies. | [References]
[1]. wang y, stowe rl, pinello ce, et al. identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class i histone deacetylases. chem biol, 2015, 22(2): 273-284. |
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