| Identification | Back Directory | [Name]
MILBEMECTIN A4 | [CAS]
51596-11-3 | [Synonyms]
milbemycinb-1
milbemycin A4
Milbemycin α3
MILBEMECTIN A4
milbemectine a4
Antibiotic B-41A4
Milbemycin oxime A4
Milbemycin EP Imp A
Milbemycin EP Impurity A
B 41A4, MilbeMycin alpha3
VOZIAWLUULBIPN-WMKNSKLVSA-N
Milbemycin Impurity 1(Milbemycin EP Impurity A)
(6R,25R)-5-O-Demethyl-28-deoxy-6,28-epoxy-25-ethylmilbemycin B
(25R)-25-Ethyl-5β-hydroxy-5-demethoxy-28-O,6β-cyclomilbemycin B
Milbemycin B, 5-O-demethyl-28-deoxy-6,28-epoxy-25-ethyl-, (6R,25R)- | [Molecular Formula]
C32H46O7 | [MDL Number]
MFCD04972570 | [MOL File]
51596-11-3.mol | [Molecular Weight]
542.7 |
| Chemical Properties | Back Directory | [Melting point ]
212-215° | [alpha ]
D20 +106° (c = 0.25 in acetone) | [Boiling point ]
732.9±60.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [storage temp. ]
0-6°C | [solubility ]
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | [form ]
A solid | [pka]
12.46±0.70(Predicted) | [color ]
White to off-white | [EPA Substance Registry System]
Milbemycin A4 (51596-11-3) |
| Hazard Information | Back Directory | [Description]
Milbemycin A4 is the prominent member of a complex family of macrocyclic lactones that contain a characteristic spiroketal group produced from the fermentation of soil bacterium S. hygroscopicus subsp. aureolacrimosus. As a compound that potentiates glutamate and GABA-gated chloride-channel opening, milbemycin 4 is used as a nematocide and insecticide. | [Uses]
Acaricide. | [Uses]
Milbemycin A4 is a macrolide compound that is a member of a complex family of macrocyclic lactones that contain structural group produced from the fermentation of soil bacterium S. hygroscopicus subsp. aureolacrimosus. Antibacterial and insecticide (1,2). It potentiates glutamate and GABA-gated chloride-channel opening. Used in the synthesis of Milbemycin A17 (3). | [Uses]
Milbemycins are a complex family of macrocyclic lactones containing a highly characteristic spiroketal group, produced by Streptomyces hydroscopicus subsp. aureolarcrimosus. Milbemycin A4 is the dominant member of a group of analogues containing a 25-ethyl substituent. Milbemycin A4 is a highly selective and potent nematocide and insecticide. Like the closely related avermectins, milbemycins are thought to act on chloride-gated ion channels. | [Definition]
ChEBI: Milbemycin A4 is a milbemycin. | [IC 50]
Macrolide |
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