| Identification | Back Directory | [Name]
1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone | [CAS]
511-26-2 | [Synonyms]
MAP4343
Pregn-5-en-20-one, 3-methoxy-, (3β)-
1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone | [Molecular Formula]
C22H34O2 | [MDL Number]
MFCD00046237 | [MOL File]
511-26-2.mol | [Molecular Weight]
330.5 |
| Chemical Properties | Back Directory | [Melting point ]
123.5° | [alpha ]
D18 +18° (c = 1.085 in chloroform) | [Boiling point ]
426.6±45.0 °C(Predicted) | [density ]
1.04±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 25 mg/mL (75.64 mM) | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents[1][2]. | [Biological Activity]
MAP4343 is a 3-methyl ether derivative of Pregnenolone. It binds to microtubule-associated protein 2 (MAP2) in vitro, stimulates the polymerization of tubulin, enhances neurite extension and protects neurons from neurotoxic agents. | [in vitro]
MAP4343 (40 μM; 15 or 30 min) stimulates microtubule polymerization in vitro. It stimulates nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. | [in vivo]
MAP4343 (12 mg/kg; daily sc for 28 d) improves the recovery of locomotor function after spinal cord injury (SCI) in rats.
MAP4343 (4 mg/kg; daily sc for 6 d) increases MAP2 levels in spinal cord after SCI in rats.
MAP4343 (4 mg/kg; daily sc for 6 d) increases the size of lumbar spinal motoneurons' dendrite arbours after SCI in rats. < p> | Animal Model: | Adult Sprague-Dawley male rats with spinal cord injury | | Dosage: | 12 mg/kg | | Administration: | Daily sc for 28 days | | Result: | Increased the number of animals able to walk with weight-supported plantar steps.
Showed forelimb-hindlimb coordination at the end of the study. | | [storage]
Store at -20°C | [References]
[1] Fontaine-Lenoir V, et, al. Microtubule-associated protein 2 (MAP2) is a neurosteroid receptor. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4711-6. DOI:10.1073/pnas.0600113103
[2] Duchossoy Y, et, al. Treatment of experimental spinal cord injury with 3β-methoxy-pregnenolone. Brain Res. 2011 Jul 27;1403:57-66. DOI:10.1016/j.brainres.2011.05.065 |
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