| Identification | Back Directory | [Name]
N2-[cis-4-[[2-[4-Bromo-2-(trifluoromethoxy)phenyl]ethyl]amino]cyclohexyl]-N4,N4-dimethyl-2,4-quinazolinediaminedihydrochloride | [CAS]
510732-84-0 | [Synonyms]
ATC 0065
ATC0065 dihydrochloride
N2-[cis-4-[[2-[4-Bromo-2-(trifluoromethoxy)phenyl]ethyl]amino]cyclohexyl]-N4,N4-dimethyl-2,4-quinazolinediaminedihydrochloride | [Molecular Formula]
C25H29BrF3N5O.2HCl | [MOL File]
510732-84-0.mol | [Molecular Weight]
625 |
| Hazard Information | Back Directory | [Uses]
ATC 0065 has a high affinity for human melanin-concentrating hormone R1 (MCHR1) with an IC50 value of 15.7±1.95. ATC 0065 is a potent and orally active MCHR1 antagonist with anxiolytic and antidepressant activity in rodents. | [in vivo]
ATC0065 (3-30 mg/kg; oral administration; 3 h prior to the test) shows antidepressant-like effects in rats[1]. | Animal Model: | Male SpragueDawley rats (190-250 g) forced swimming[1] | | Dosage: | 3 mg/kg, 10 mg/kg, 30 mg/kg | | Administration: | Oral administration; 3 h prior to the test | | Result: | Significantly reduced immobility time in the forced swimming. |
| [storage]
Desiccate at RT |
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