| Identification | Back Directory | [Name]
13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1 | [CAS]
5094-14-4 | [Synonyms]
U 21002
13,14-dihydro-15-keto PGE1
CDUVSQMTLOYKTR-ZHALLVOQSA-N
13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1
9,15-dioxo-11α-hydroxy-prostan-1-oic acid
9,15-DIOXO-11ALPHA-HYDROXY-PROSTAN-1-OIC ACID
Prostan-1-oic acid, 11-hydroxy-9,15-dioxo-, (11α)-
15-Keto Prostaglandin E0
DISCONTINUED, OFFER K202056 | [Molecular Formula]
C20H34O5 | [MDL Number]
MFCD00135210 | [MOL File]
5094-14-4.mol | [Molecular Weight]
354.49 |
| Chemical Properties | Back Directory | [Boiling point ]
537.2±35.0 °C(Predicted) | [density ]
1.072±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly), THF (Slightly) | [form ]
Oil | [pka]
4.77±0.10(Predicted) | [color ]
Dark Yellow |
| Hazard Information | Back Directory | [Description]
13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity. Steady state plasma concentrations are about 10 pg/ml. 13,14-dihydro-15-keto PGE1 is a weak inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 54 and 200 μM, respectively, compared to PGE1 which has an IC50 of 40 nM. | [Uses]
15-Keto Prostaglandin E0 is a metabolite of Prostaglandin E1 (P838600) and has been shown to induce arterial thromboresistance in experimental animals and in man, but with several magnitudes higher concentrations than Prostaglandin E1. 15-Keto Prostaglandin E0 is also used as the active ingredient in compositions used for the treatment of external secretion disorders. | [Definition]
ChEBI: 13,14-dihydro-15-oxoprostaglandin E1 is a prostaglandin E obtained by formal oxidation of the 15-hydroxy group and hydrogenation of the 13,14-double bond of prostaglandin E1. It has a role as a human xenobiotic metabolite. It is functionally related to a prostaglandin E1. It is a conjugate acid of a 13,14-dihydro-15-oxoprostaglandin E1(1-). |
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Energy Chemical
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Resenbio
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www.xarxbio.com |
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