| Identification | Back Directory | [Name]
tingenin B | [CAS]
50656-68-3 | [Synonyms]
tingenin B
22β-Hydroxymaytenin
22β-Hydroxytingenone
3,22β-Dihydroxy-24,29-dinorfriedela-1(10),3,5,7-tetrene-2,21-dione
3,22β-Dihydroxy-24,29-dinor-D:A-friedoolean-1(10),3,5,7-tetrene-2,21-dione
24,25,26,30-Tetranoroleana-1(10),3,5,7-tetraene-2,21-dione, 3,22-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20β,22β)- | [Molecular Formula]
C28H36O4 | [MOL File]
50656-68-3.mol | [Molecular Weight]
436.58 |
| Hazard Information | Back Directory | [Description]
Tingenin B, the plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro. This compounds target cancer stem cells (CSCs), Tingenin b was cytotoxic against MCF-7s (IC50 value for 48 h was found to be 2.38 μM) by inducing apoptosis. It was evident by Annexin V staining positivity, decreased mitochondrial membrane potential and Bcl-2 dephosphorylation with a concomitant increase in Bax protein expression. In addition, endoplasmic reticulum stress was also found to be involved in tingenin b-induced cell death. |
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