| Identification | Back Directory | [Name]
NSC 377363 | [CAS]
502139-01-7 | [Synonyms]
NSC 377363
Synucleozid
Synucleozid dihydrochloride
Synucleozid dihydrochloride 2-(4-((4-carbamimidoylphenyl)amino)phenyl)-1H-indole-6-carboximidamide | [Molecular Formula]
C22H20N6 | [MDL Number]
MFCD34470022 | [MOL File]
502139-01-7.mol | [Molecular Weight]
368.43 |
| Hazard Information | Back Directory | [Biological Activity]
Synucleozid (NSC 377363) is a potent inhibitor of the SNCA mRNA that encodes α-synuclein protein (IC50=1.5 μM). Synucleozid selectively targets the α-synuclein mRNA 5′ UTR at the designed IRE site, decreases the amount of SNCA mRNA loaded into polysomes and thereby inhibits SNCA translation. Synucleozid has the potential for the investigation of Parkinson's disease[1]. | [storage]
Store at -20°C | [References]
[1]. Zhang P, et al. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA.Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1457-1467. |
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DC Chemicals
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