| Identification | Back Directory | [Name]
NS 1738 | [CAS]
501684-93-1 | [Synonyms]
NS 1738
NSC 213859
1-(5-Chloro-2-hydroxy-phenyl)-3-(2-chloro-5-trifluoromethyl-phenyl)-urea
N-(5-Chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea
Urea, N-(5-chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]- | [Molecular Formula]
C14H9Cl2F3N2O2 | [MDL Number]
MFCD11100189 | [MOL File]
501684-93-1.mol | [Molecular Weight]
365.13 |
| Chemical Properties | Back Directory | [Boiling point ]
344.1±42.0 °C(Predicted) | [density ]
1.617±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
White crystalline solid. | [pka]
8.08±0.13(Predicted) | [color ]
Off-White to Light Grey |
| Hazard Information | Back Directory | [Description]
NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs). When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through α7-containing nAChRs (EC50 = 3.4 μM). NS 1738 displays no substantial activity for α4β2-, α3β3-, and α1-containing receptors. It is modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats. NS 1738 also improves performance in the rat social recognition test. NS 1738 is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways. | [Uses]
NS 1738 is a selective a7 nAchR allosteric modulator. | [Biological Activity]
Selective positive allosteric modulator of α 7 nicotinic acetylcholine receptors. Exhibits no substantial activity for α 4 β 2, α 3 β 3 and α 1-containing receptors. Displays cognitive-enhancing properties in vivo . | [storage]
Store at RT |
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