| Identification | Back Directory | [Name]
Aloisine B | [CAS]
496864-14-3 | [Synonyms]
Aloisine B
5H-Pyrrolo[2,3-b]pyrazine, 6-(4-chlorophenyl)-7-(1-methylethyl)- | [Molecular Formula]
C15H14ClN3 | [MOL File]
496864-14-3.mol | [Molecular Weight]
271.74 |
| Hazard Information | Back Directory | [Description]
Aloisine B is a potent and selective CDK and GSK-3 inhibitor. Highest affinity targets: Glycogen Synthase Kinase-3, Beta (Rattus norvegicus (rat)) (IC50 750.0 nM). Other measured targets: Cyclin-Dependent Kinase 1 (CDK1) (IC50 850.0 nM); Cyclin-Dependent Kinase 5 (CDK5) (IC50 13000.0 nM). Aloisine inhibits cell proliferation by arresting cells in both G1 and G2. |
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